85 example adult leukemia chromosome karyotype analysis

Objective This article aims to analyze 85 cases of adult leukemia patients with chromosome abnormalities and the distribution of karyotype changes in the characteristics of subtypes.Methods According to clinical manifestations,hemogram,bone marrow and cell staining,as a preliminary to determine the diagnosis of leukemia.Then morphology,immunology,cytogenetics,molecular biology testing.Results Different types of leukemia patients have a chromosome test results markedly different from that in AML,ALL,CML,CLL,CMML patients,the abnormal karyotype were 64.4% (38/59),73.3% (11/15),100% (5/5),66.7% (2/3),66.7% (2/3),the average chromosome abnormality accounted for 68.2% (58/85).From a variety of leukemia chromosome abnormalities characteristic,in addition to the number of cases of leukemia with fewer chromosomal abnormalities are not comparable things,M3 and CML compared with the same chromosomal changes,respectively,t (15;17) (q22;q11.2);t (9;22) (q34;q11.2) changes in the main;while other types of leukemia,there are inconsistencies chromosomal abnormalities,especially the M4 there is a clear inconsistency.Conclusions According to leukemia,abnormal chromosome karyotype analysis,a complex karyotype is a sign of poor prognosis.Some of the specific chromosomal abnormalities and the FAB subtypes closely related.Therefore,the chromosomal abnormality karyotype analysis in leukemia diagnosis,classification,treatment and prognosis aspects play an important role.