Efficacy and safety of postoperative analgesia with flurbiprofen axetil and fentanyl after off-pump coronary artery graft bypass

Objective:To assess the efficacy and safety of postoperative analgesia with intravenous flurbiprofen axetil and fentanyl after off-pump coronary artery graft bypass.Methods: One hundred patients were randomly allocated to 5 groups(n=20 for each group).The patients were treated with one of the following regimens:(A) postoperative fentanyl 2mg in 200mL 0.9% NaCl;(B) preoperative flurbiprofen axetil 100mg and postoperative fentanyl 2mg in 200mL 0.9% NaCl;(C) postoperative flurbiprofen axetil 100mg+fentanyl 2mg in 200mL 0.9% NaCl;(D) preoperative flurbiprofen axetil 100mg and postoperative flurbiprofen axetil 100mg+ fentanyl 2mg in 200mL 0.9% NaCl;(E) preoperative flurbiprofen axetil 100mg and postoperative flurbiprofen axetil 200mg+ fentanyl 1mg in 200mL 0.9% NaCl.Pain scores at rest and adverse effects were recorded.Results: No significant differences were found in the age,body mass index and operative duration among the five groups.At 24 to 48h after surgery,the VAS in patients treated with additional flurbiprofen axetil(regimens B,D,E) was significantly lower than in patients without flurbiprofen axetil(regimen A).There were no significant differences in VAS between patients with regimans A/C and the other groups at various time points.The incidence of nausea was higher in patients with preoperative and postoperative flurbiprofen(regimen D) than in other 3 flurbiprofen groups.Conclusion: Peri-operative analgesia with addition of flurbiprofen axetil to fentanyl has more perfect analgesic effect and low adverse effects than with fentanyl alone.