THE INFLUENCING OF OLANZAPINE TO THE BLOOD DRUG LEVEL OF CLOZAPINE AND THE TREATMENT EFFECT OF SCHIZOPHRENIA

ObjectiveTo explore the enfulencing of olanzapine to the blood drug level of clozapine and treatment effect of schizophrenia.Methods50 schizophrenia patients with long term taking clozapine for more than one year were randomly divided into two groups,26 patients were recruited as controls who treated with clozapine at the dose of 200 to 500 mg per day,while 24 patients in experiment group were treated with clozapine at the dose of 200 to 500 mg per day and olanzapine at the dose of 5 to 15 mg per day for 12 weeks. The therapeutic effect was evaluated with positive symptoms and measuring scale of positive symptoms,and the steady plasma-drug concentration of clozapine was determined with HPLC.ResultsThe blood drug level of clozapine at the time of 12 weekend did not showed significantly difference in the two group(P﹤0.05). The total scale of PANSS showed significant decreased before and after treatment in the two groups(P﹤0.05),while the total scale of PANSS at the same time did not revealed significantly decreased,the scale of positive symptoms did not found significant difference as well(P﹥0.05). When compared with control group,the scale of positive symptoms among the experiment group did not significantly improved(P﹤0.05).ConclusionSchizophrenia patients treated with combination of olanzapine and clozapine did not influence the blood drug level and therapeutic effect of clozapine for schizophrenia,which could improve the positive symptoms of schizophrenia to some extence.