Clinical Significance of Changes of Serum 8-iso-PGF_(2α),SOD and MDA Levels in Patients with Hypertension

Objective To explore the changes of serum 8-iso-PGF2α,superoxide dismutase(SOD) and malondialdehyde(MDA) levels in patients with essential hypertension.Methods The content of 8-iso-PGF2α,SOD and MDA levels in 193 cases of essential hypertension and 52 controls were detected by using ELESA,xanthine oxidase and thiobarbituric acid method.Results The serum 8-iso-PGF2α levels in patients were obviously higher than those in controls(P0.05),the SOD levels were significantly lower than those in controls(P0.01) and the MDA levels were significantly higher than those in controls(P0.01).When the blood pressure increased,the content of SOD was decreased,and there was a significantly negative correlation(r=-0.74).But to the 8-iso-PGF2α and MDA,when the blood pressure increased the content of them was increased,There was a significantly positive correlation between the blood pressure with 8-iso-PGF2α and MDA levels respectively(r=0.62,r=0.81).Conclusion The levels of serum 8-iso-PGF2α,SOD and MDA are closely correlated to the severity of hypertension,and they may be used for evaluation of patients with hypertension.