Evaluation of the efficacy of olsalazine combined with dexamethasone in treating patients with ulcerative colitis

[Objective]To evaluate the efficacy and safety of retention enema of olsalazine in combination with dexamethasone in the treatment of ulcerative colitis.[Methods]Fifty cases of ulcerative colitis patients were divided into observation group and control group randomly,and twenty-six persons in observation group treated with olsalazine in combination with dexamethasone retention enema,twenty-four persons in control group treated with sulfasalazine pyrimidine in combination with dexamethasone retention enema.The disease activity index,total efficiency rates and side effects of two groups were compared one and two months later.[Results]No significant difference of the DAI index was found between the two groups before treatment(P 0.05).After one-month-treatment,the DAI index of two groups was significantly lower than that before treatment respectively(P0.05),and the difference between the two groups was not significant(P0.05).Two months later,the DAI indexes were decreased significantly compared with those before treatment(P0.01),and the observation group was remarkably lower than the treatment group(P0.05).[Conclusion]Olsalazine in combination with dexamethasone retention enema is a safe and effective treatment for patients with ulcerative colitis,which is worthy of clinical application.