2002•Unpublished venueRequires access
Change of Bax,Bc1-2 Expression in Cerebral Cortex Following Local Ischemi
Gao Yu-pei
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Abstract
In order to explore the change of Bax, Bc1-2 expression in cerebral cortex at 6?h following ischemia, rats were performed local ischemia operation derived from middle cerebral artery block. Rats were sacrificed at 6?h following ischemia. The cerebral cortex was taken and sectioned into 20?μm frozen section. The sections were stained using antibody of Bax, Bc1-2 by ABC immunohistochemical technique. The gray degree of Bax,Bc1-2 was measured by imagine analysis system. Results: At 6h following ischemia, the gray degree of Bax, Bc1-2 in neurons of cortex in control is respectively 84.7±4.4, 91.3±5.5 and 73.1±6.6, 107.7±9.1. It showed that expression of Bax was upregulated and Bc1-2 expression was decreased following ischemia.