Clinical significance of the changes of serum tumor necrosis factor-a and C-reactive protein levels in patients with acute coronary syndrome

Objective To investigate the clinical significance of the changes of serum tumor necrosis factor (TNF-α) and C-reactive protein (CRP) levels in patients with acute coronary syndrome (ACS) .Methods The serum levels of TNF-α and CRP were detected in 50 patients with ACS (ACS group) ,50 patients with stable angina pectoris (SAP group) and 50 healthy subjects(control group). Results The serum levels of TNF-α and CRP in ACS group were higher than those in SAP group and control group ( P 0.01); among the patients with ACS, the serum TNF-α and CRP levels in AMI patients were higher than those of UAP group ( P 0.05) .There was no significant difference in the levels of TNF-α and CRP between SAP group and control group ( P 0.05) .There was a positive correlation between TNF-α and CRP levels ( r = 0. 5246, P 0.01). Conclusion TNF-α and CRP are correlated with pathogenesis of ACS and may reflect the seventy of ACS.