Control study on curative effect of oxcarbazepine and carbamazepine on post stroke secondary epilepsy

Objective To compare the curative effect of oxcarbazepine and carbamazepine on post stroke secondary epilepsy( PSE). Methods A total of 104 PSE patients were divided into oxcarbazepine group and carbamazepine group randomly with 52 cases in each group,which were given oxcarbazepine and carbamazepine treatment respectively on the base of conventional therapy with the course of treatment for 3 months. The clinical effect,electroencephalogram( EEG) and untoward reaction were compared between the 2 groups. Results The total effective rate in oxcarbazepine group( 88. 5%) was high significantly than that in carbamazepine group( 61. 5%),the difference had statistical significance( P 0. 05). The number of EEG epilepsy discharge and lead involved in the 2 groups were significantly decreased after treatment compared with before treatment,which in oxcarbazepine group was decreased significantly compared with those in carbamazepine group( P 0. 05). The untoward reaction rate in oxcarbazepine group( 7. 7%) was significantly lower than that in carbamazepine group( 13. 5%)( P 0. 05). Conclusion Oxcarbazepine therapy on PSE has satisfactory outcome and reliable drug safety.