Comparative study the single drug treatment with Oxcarbazepine and Carbamazepine on children with partial epilepse

Objective To compare the efficacy of the single drug treatment with Oxcarbazepine and Carbamazepine on children with partial epilepse.Methods By the number of single or double,71 new diagnostic children with partial epilepse were divided into Oxcarbazepine group(35 cases)and Carbamazepine group(36 cases),and received the certain drug therapy.The efficacy was evaluated 6 months post treatment. The adverse reaction during the treatment was obseved.Results 25 cases in Oxcarbazepine group and 29 cases in Carbamazepine group completed the treatment for 6 months.The improving rates of EEG were 44.0% and 44.8%,the obvious effect rates were 92.0% and 86.2%,and the adverse reaction rates were 22.2% and 41.2% in groups Oxcarbazepine and Carbamazepine,respectively. There was no significantly difference in the two groups(all P0.05). The 2 cases in Carbamazepine group appeared severe complications.Conclusions There are significant curative effects of single drug treatment with Oxcarbazepine and Carbamazepine on new diagnostic children with partial epilepse,and the adverse reaction and tolerance are similar. The severe complication is not appeared in Oxcarbazepine group.