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2010•Chinese Journal of MisdiagnosticsRequires access

Relationships between Levels of CTGF、TGF-β_1 Gen Expressions in Liver Tissues and Fibrosis Pathology

Xiaoshen Li

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Abstract

Objective:To investigate the relationship between fibrosis pathology and the levels of CTGF,TGF-β1 gen expressions in liver tissues.Methods:All rats were given subcutaneous injection of pig serum after 16 weeks,the degrees of fibrosis was detected by histopathology under optical microscopy.The expressions of CTGF,TGF-β1 were measured by immunochemical techniques.Results:The model group had shown typical hepatic fibrosis.The expressions of TGF-β1,connective tissue growth factor increased obviously.Conclusion:The study indicates that TGF-β1 and CTGF accelerate the development of experiment liver fibrosis.

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What this paper is about

Objective:To investigate the relationship between fibrosis pathology and the levels of CTGF,TGF-β1 gen expressions in liver tissues.Methods:All rats were given subcutaneous injection of pig serum after 16 weeks,the degrees of fibrosis was detected by histopathology under optical microscopy.The expressions of CTGF,TGF-β1 were measured by immunochemical techniques.Results:The model group had shown typical hepatic fibrosis.The expressions of TGF-β1,connective tissue growth factor increased obviously.Conclusion:The study indicates that TGF-β1 and CTGF accelerate the development of experiment liver fibrosis.

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Available abstract

Objective:To investigate the relationship between fibrosis pathology and the levels of CTGF,TGF-β1 gen expressions in liver tissues.Methods:All rats were given subcutaneous injection of pig serum after 16 weeks,the degrees of fibrosis was detected by histopathology under optical microscopy.The expressions of CTGF,TGF-β1 were measured by immunochemical techniques.Results:The model group had shown typical hepatic fibrosis.The expressions of TGF-β1,connective tissue growth factor increased obviously.Conclusion:The study indicates that TGF-β1 and CTGF accelerate the development of experiment liver fibrosis.

Key concepts: CTGF, Histopathology, Fibrosis, Connective tissue, Pathology, Transforming growth factor, Medicine, Liver fibrosis

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Relationships between Levels of CTGF、TGF-β_1 Gen Expressions in Liver Tissues and Fibrosis Pathology — Research Paper | ScholarLens