Expression of connective tissue growth factor-mRNA in experimental hepatic fibrosis

Objective To study the expression of connective tissue growth factor(CTGF)-RNA in mouse experimental hepatic fibrosis and its significance. Methods The liver tissue gene levels of CTGF were measured by reverse transcription polymerase chain reaction (RT-PCR) in 52 male Kunming mice with experimental hepatic fibrosis. Results The expression levels of CTGF were higher in hepatic fibrosis group than those in control group, they were closely associated with hepatic fibrosis development (r=0.582, P0.01). Conclusion The mRNA expression of CTGF is remarkably up-regulated in mouse hepatic fibrosis. This result indicates that CTGF plays an important role in the activation and domination of hepatic fibrosis.