CHANGES OF SERUM AND URINE CYSTATIN C IN RENAL INJURY PATIENTS

[Objective]To observe the changes of serum and urine cystatin C in patients with renal injury and investigate the clinical significance of serum,urine cystatin C determination.[Methods]There were 80 cases of renal injury patients,60 healthy cases as control group.Determined the serum,urine cystatin C and serum,urinary β2-microglobulin(β2-MG)with ELISA,while tested the serum creatinine(Scr),serum urea nitrogen,creatinine clearance rate(Ccr)and 24-hour urine protein.[Results]Serum cystatin C(P﹤0.01),serum β2-MG(P﹤0.05),urinary cystatin C(P﹤0.01),urinary β2-MG(P﹤0.05),the ratio of urinary cystatin C to urinary creatinine(u[cystatin C/Cr])(P﹤0.01)and the ratio of urinary β2-MG to urinary creatinine(u[β2-MG/Cr])(P﹤0.05)in patients with chronic glomerulonephritis were significantly higher than those in the control group;serum cystatin C(P﹤0.05),serum β2-MG(P﹤0.01),urine cystatin C(P﹤0.05),urinary β2-MG(P﹤0.01),the ratio of u[cystatin C/Cr](P﹤0.01)and the ratio of u[β2-MG/Cr](P﹤0.01)in patients with diabetic nephropathy were significantly higher than those in the control group;serum cystatin C,serum β2-MG,urine cystatin C,urinary β2-MG,the ratio of u[cystatin C/Cr]and the ratio of u[β2-MG/Cr]in patients with hypertensive nephropathy were significantly higher than those in the control group(P﹤0.01).The sensitivities of serum β2-MG and serum cystatin C were higher than that of serum creatinine.[Conclusion]Serum cystatin C is the sensitive indicator of changes in GFR.By detecting urinary cystatin C can find renal tubular damage in chronic glomerulonephritis patients,diabetic nephropathy patients and hypertensive nephropathy patients.