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Screening of combined detection of tumor markers for common malignant tumors

DU Guo-you

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Abstract

Objective To explore the sensitivity and specificity of combined detection of serum AFP,CEA and CA199 in common malignant tumors.Methods Serum levels of AFP,CEA and CA199 were measured with chemiluminescent immunoassay(CLIA)in patients with common malignant tumors or benign diseases and healthy adults.The sensitivity and specificity of the serum markers were evaluated and compared.Results The sensitivity of AFP and CA199 was higher than that of CEA in patients with hepatocarcinoma,while the sensitivity of CEA and CA199 were higher than that of AFP in patients with lung cancer and carcinoma of large intestine.The sensitivity of CA199 was higher in patients with common malignant tumors.Compared with that of benign diseases group and healthy control group,the positive result of one or more serum markers in patients with common malignant tumors was more frequent than that of combined detection of three tumor markers.The difference was statistically significant.Conclusion Combined detection of three serum tumor markers(AFP,CEA and CA199)contributes to the improvement of early detection rate of common malignant tumors.

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What this paper is about

Objective To explore the sensitivity and specificity of combined detection of serum AFP,CEA and CA199 in common malignant tumors.Methods Serum levels of AFP,CEA and CA199 were measured with chemiluminescent immunoassay(CLIA)in patients with common malignant tumors or benign diseases and healthy adults.The sensitivity and specificity of the serum markers were evaluated and compared.Results The sensitivity of AFP and CA199 was higher than that of CEA in patients with hepatocarcinoma,while the sensitivity of CEA and CA199 were higher than that of AFP in patients with lung cancer and carcinoma of large intestine.The sensitivity of CA199 was higher in patients with common malignant tumors.Compared with that of benign diseases group and healthy control group,the positive result of one or more serum markers in patients with common malignant tumors was more frequent than that of combined detection of three tumor markers.The difference was statistically significant.Conclusion Combined detection of three serum tumor markers(AFP,CEA and CA199)contributes to the improvement of early detection rate of common malignant tumors.

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Available abstract

Objective To explore the sensitivity and specificity of combined detection of serum AFP,CEA and CA199 in common malignant tumors.Methods Serum levels of AFP,CEA and CA199 were measured with chemiluminescent immunoassay(CLIA)in patients with common malignant tumors or benign diseases and healthy adults.The sensitivity and specificity of the serum markers were evaluated and compared.Results The sensitivity of AFP and CA199 was higher than that of CEA in patients with hepatocarcinoma,while the sensitivity of CEA and CA199 were higher than that of AFP in patients with lung cancer and carcinoma of large intestine.The sensitivity of CA199 was higher in patients with common malignant tumors.Compared with that of benign diseases group and healthy control group,the positive result of one or more serum markers in patients with common malignant tumors was more frequent than that of combined detection of three tumor markers.The difference was statistically significant.Conclusion Combined detection of three serum tumor markers(AFP,CEA and CA199)contributes to the improvement of early detection rate of common malignant tumors.

Key concepts: Medicine, Chemiluminescent immunoassay, Carcinoembryonic antigen, Lung cancer, Tumor marker, Internal medicine, Cancer, Pathology

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