Preparing rutin gelatin microspheres and characterization

In this study the single factor experiment and orthogonal experimental were designed to optimize the best techniques of preparing rutin gelatin microspheres.Rutin gelatin microspheres were prepared by emulsion chemical-cross linking method with degradable gelatin as carrier,liquid paraffin as oil phase,Span80 as emulsifier,and the technique reproducibility of microspheres was studied.The surface morphology of the microspheres was observed by SEM,the formation of the drug microspheres was confirmed by FT-IR and XRD.The drug loading,the encapsulation efficiency and stability of the microsphere were examined.Microspheres with good shape,smooth surface and narrow size distribution were prepared.The average diameter of microspheres was 5~20 μm,the loading amount of medicine was 3.55% and encapsulation efficiency was 94.5%.