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2005•Journal of Inorganic MaterialsRequires access

Preparation and Characterization of Magnetic Nornoxacin Gelatin Microspheres

Yan Wang

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Abstract

Based on the biological compatibility of gelatin in water and its solidification by glu-taradehyde, the magnetic norfloxacin gelatin core-shell microspheres were prepared by means of the reverse phase suspension cold-condensation method using FesO4 as core and glutaric dialde-hycle as dispersed medium. The products were characterized by IR, SEM, TEM, UV/Vis. The results show that the microspheres are spherical in shape with smooth surfaces. The diameter of the microspheres is in the rang from 5 to 10μm, The content of drug in microspheres is 6.2% and of Fe3O4 is 19%. The drug encapsulation efficiency is 61.4%, the quantity of drug released from microspheres in 5 hours is 74.4%. The microspheres have good properties of drug sustain releasing.

About this research paper

What this paper is about

Based on the biological compatibility of gelatin in water and its solidification by glu-taradehyde, the magnetic norfloxacin gelatin core-shell microspheres were prepared by means of the reverse phase suspension cold-condensation method using FesO4 as core and glutaric dialde-hycle as dispersed medium. The products were characterized by IR, SEM, TEM, UV/Vis. The results show that the microspheres are spherical in shape with smooth surfaces. The diameter of the microspheres is in the rang from 5 to 10μm, The content of drug in microspheres is 6.2% and of Fe3O4 is 19%. The drug encapsulation efficiency is 61.4%, the quantity of drug released from microspheres in 5 hours is 74.4%. The microspheres have good properties of drug sustain releasing.

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Available abstract

Based on the biological compatibility of gelatin in water and its solidification by glu-taradehyde, the magnetic norfloxacin gelatin core-shell microspheres were prepared by means of the reverse phase suspension cold-condensation method using FesO4 as core and glutaric dialde-hycle as dispersed medium. The products were characterized by IR, SEM, TEM, UV/Vis. The results show that the microspheres are spherical in shape with smooth surfaces. The diameter of the microspheres is in the rang from 5 to 10μm, The content of drug in microspheres is 6.2% and of Fe3O4 is 19%. The drug encapsulation efficiency is 61.4%, the quantity of drug released from microspheres in 5 hours is 74.4%. The microspheres have good properties of drug sustain releasing.

Key concepts: Gelatin, Materials science, Microsphere, Chemical engineering, Drug delivery, Spray drying, Nanotechnology, Organic chemistry

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