Study on Techniques of Preparing Baicalin Gelatin Microspheres

Objective To optimize the best techniques of preparing baicalin gelatin microspheres with orthogonal experimental design.Methods Baicalin gelatin microspheres were prepared by emulsion chemical-cross linking method with degradable gelatin as carrier,liquid paraffin as oil phase,Span-80 as emulsifier.The particle size,containing efficiency of microspheres were determined and technique reproducibility was studied.Results Microspheres with good shape,smooth surface and narrow size distribution were prepared.The average diameter of microspheres was 27.47 μm,the loading amount of medicine was 8.18% and encapsulation efficiency was 70.21%.Conclusion The preparation procedure established was stable and practical.