Comparative study on antiprotoscoleces of echinococcus granulosus in vitro using oxibendazole、albendazole and lipsomal albendazole

Objective: The effect of antihydatidosis of oxibendazole、albendazole and lip albendazole on protoscoleces of echinococcus granulosus was compared in vitro. Methods: Protoscoleces of echinococcus granulosus was cultured in the different concentration(high、middle、low) of oxibendazole、albendazole and lip albendazole in 1640 culture media respectively in vitro. The daily mortality in each group was counted until the day of the protoscoleces of control completely dead. Results: The significant difference of the mortality between the three drugs with various concentrations and the control group was found respectively(P0.05); however,in lip albendazole group the statistic difference only in high concentrations was found(P0.05); the antiprotoscoleces effect of these drugs compared each other, no statistic differences was found(P0.05). Conclusions: The significant antiprotoscoleces effect of the three drugs was found in vitro. Oxibendazole, a new anti hydatid drug,had the similar antiprotoscoleces effect with albendazole in vitro;there was no significant effect on their antiprotoscoleces by the formulation changing between albendazole.and lip albendazole only in vitro.