COMPARATIVE STUDY ON THREE DRUGS AGAINST ECHINOCOCCUS GRANULOSUS PROTOSCOLECES IN VITRO

Objective Anti hydatid efficacy for Echinococcus granulosus protoscoleces( Eg PSC) was investigated by using Oxibendazole (OBZ), Albendazole (ABZ) and Liposomal Albendazole (L ABZ) in vitro . Methods Eg PSC was cultured in three drugs concentrations 2 500 ng/ml, 500 ng/ml, 100 ng/ml) of OBZ, ABZ and L ABZ in the RPMI1640 culture media respectively. The mortality in each group was daily counted until 100% Eg PSC death in control. Results Significant difference of Eg PSC mortality was found among these three drugs with various concentrations compared to control group ( P 0.05); In L ABZ group, however the statistical difference was found only in high concentrations( P 0.05). Conclusion The significant anti protoscolece effect for these three drugs was found in our current experiment in vitro . OBZ had the similar anti hydatid effect compared with ABZ in vitro , which could be considered as a potential candidate drug against E. granulosus . L ABZ did not demonstrate the significant effect of anti hydatid Eg PSC in vitro .