Drug resistance analysis on multiple drug resistant and pan-resistant Acinetobacter baumannii carried by children

Objective: To analyze drug resistance of 142 Acinetobacter baumannii strains clinically separated in pediatric department of this hospital and Hebei Children's Hospital,provide a theoretical basis for clinically reasonable application of antibiotics in treatment of multiple drug resistant and pan- resistant Acinetobacter baumannii carried by children,improving use efficiency of antibiotics,reducing the incidence rate of multiple drug resistant Acinetobacter baumannii infection and improving the curative effect. Methods: K- B paper disk diffusion method was used to conduct drug resistance test of 19 kinds of antibiotics,the diameters of complete inhibition zone and paper were measured by vernier caliper. Inhibition ring test was performed,and the results were interpreted according to M100,drug resistance rates of the tested bacteria were reported. Results: Among 142 Acinetobacter baumannii strains,72 multiple drug resistant Acinetobacter baumannii strains,24 pan- resistant Acinetobacter baumannii strains and 46 non- multiple drug resistant Acinetobacter baumannii strains were included. Drug resistance rates of multiple drug resistant Acinetobacter baumannii and pan- resistant Acinetobacter baumannii to cephalosporins,hydrocarbon enzyme alkenes medicine,aminoglycosides,penicillins,quinolones,tetracyclines and sulfonamides were 41. 00%- 99. 00%,while the drug resistance rate to polymyxins was 0. Conclusion: Drug resistances of 142 Acinetobacter baumannii strains separated from pediatric wards to 19 kinds of antibiotics increase gradually,the drug resistance analysis suggests that combination drug therapy can improve clinical efficacy.