Effects of chelerythine on hepatic pathology and hydroxyproline level in rats with CCl4-induced hepatic fibrosis

Objective To observe the antifibrotic effects of chelerythine in rats with CCl4-induced hepatic fibrosis.Methods Hepatic fibrosis models in rats were established by injection of tetrachloride,in combination with the control of nutrition and the drinking 10% of alcohol.Four weeks later,chelerythine and γ-interferon were used in two groups respectively,for comparison to control and fibrotic model group.At the end of eight weeks,the histological changes and hydroxyproline content were detected.Result The pathological fibrosis scores and liver hydroxyproline content in rats with chelerythine or γ-interferon intervention decreased significantly as compared with fibrotic model group(P0.01),and the effect of chelerythine was found to be in a dose-dependent manner.Conclusions Chelerythine can improve the hepatic injuries in rats with tetrachloride-induced hepatic fibrosis.