Effects of Chelerythrine on the Serum ALT and HA Level of Hepatic Fibrosis in Rats

Objective To observe the curative effects of chelerythrine on the serum ALT and HA level of CCl4-induced hepatic fibrosis in rats.Methods Models of hepatic fibrosis were established by hypodermic injection of tetrachloride,in combination with the control of nutrition and the drinking of 10% alcohol to rats.According to histological sections,hepatic fibrosis in rats emerged at the end of the fourth week.Subsequently different doses of chelerythrine was used to treat hepatic fibrosis in rats.In addition,normal control group,fibrotic model group,γ-interfom group in experiment was arranged.At the end of the eighth week of treatment,serum hyaluronic acid level,alanine aminotransferase of all the rats were detected.Results Compared with fibrotic model group,all chelerythrine groups could decreased significantly the serum HA level of hepatic fibrosis in rats induced by CCL4(P0.01),which was not obviously distinguished from γ-interfom group(P0.05),while the serum ALT level of hepatic fibrosis in rats was not obviously different among all chelerythrine groups,IFN-γ group and fibrotic model group.Conclusions Chelerythrine can reduce the serum HA level of hepatic fibrosis,and the anti-fibrotic effects of chelerythine are identical with IFN-γ.But chelerythine could not improve the serum ALT level and protect live cell of hepatic fibrosis in rats.