Expression of VEGF and the correlation with ER and PR in breast cancer

Objective:To study the expression of VEGF and the correlation between VEGF expression and ER,PR in breast cancer.Methods:The expression of VEGF,ER and PR was detected by immunohistochemistry(streptavidin-peroxidasse,SP) in breast cancer.Results:The positive rates of VEGF in breast cancer and the control were respectively 70.0%(42/60) and 10.0%(2/20).The difference was significant(P0.01).In 60 breast cancers,there were 37 ER positive cases(37/60,61%) and 36 PR positive cases(36/60,60%).The expression of VEGF was negative correlated with ER indexes(P0.05),significantly correlated with lymphnode metastasis and histologic grade.But it was not correlated with PR indexes,age,gender and histologic grade(P0.05).Conclusion:The up-regulated expression of VEGF in breast cancer indicates that VEGF may play an important role in tumorigensis and progression of breast cancer.Therefore,the combined detection of VEGF,ER and PR in breast cancer is helpful for curing the cancer and estimating its prognosis.To some extent,this has important clinical value.