Study on the Expression of ATlreceptor,VEGF,MVD and Their Correlations in Breast Cancer

Objective:To study the expression of ATlreceptor,VEGF,CD34 and their correlation in breast cancer. Methods:The expression of ATlreceptor,VFGF,CD34 in paraffin-embedded breast cancer for 102 cases was detected by im- munohistochemical technique(SP).Results:The positive expression rate of ATlreceptor was 48% in breast cancer.There were 61.8% ATlreceptor with lymphnode metastasis while 31.9% without lymphnode metastasis in breast cancer(P＜0.05).The positive expression rate of VEGF was 40.2% in breast cancer,44.4% with lymphnode metastasis and 23.5% without it(P＜0.01).In the ATlreceptor group of negative expression,the positive expression rate of VEGF was 11.3%(6/53),while in the ATlreceptor group of posidve expression,it was 71.4%(35/49),with an obvious difference(P＜0.05).The MVD was 17.349±5.67 in the breast cancer of negative expression of AT1 receptor,while it was 20.37±7.30 in the breast cancer of positive expression of AT1 receptor.And it was 17.14±5.78 in the breast cancer of negadve expression of VEGF while 21.27±7.14 in the breast cancer of positive expression of VEGF.The difference was remarkable(P＜0.05).Conclusion:The positive expression rate of ATlreceptor and VEGF was 48% and 40.2%,respectivdy.Neither of the expression of ATlreceptor and VEGF was related with age,tumor size,ER or PR,but both have a posidve correlation with lymphnode metastasis.The ATlreceptor also has a positive correlation with VEGF.In the breast cancer,MVD,AT1 receptor and VEGF,they all have a positive correladon with each other as well.