2011•Medicine & Philosophy(Clinical Decision Making Forum Edition)Requires access
Expression and Clinical Significance of Melatonin Receptor(MT1) in Osteosarcoma
Yang Zhi-pin
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Abstract
Immunohistochemical method was used to detect the expression of MT1 in 40 cases of osteosarcoma and 20 cases of osteochondroma tissues.There was a significant overexpression of MT1 in osteosarcoma tissues as compared with osteochondroma tissues.The difference was significant(P0.05).Furthermore,the expression of MT1 in osteosarcoma tissues was correlated with Enneking's Staging,recurrence and metastasis(P0.05),but not with gender、age、tumor volume and Dahlin's differentiation(P0.05).MT1 may become a useful marker for evaluating prognosis of osteosarcoma patients.These findings may have implications for the use of melatonin in osteosarcoma therapy.