2014•Hainan Yixueyuan xuebaoRequires access
Expression and clinical significance of Bag-1 in glioma
LI Fu-xion
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Abstract
Objective:To explore the expression and clinical significance of Bcl-2-associated athanogene-1(BAG-1)in human gliomas.Methods:The protein level of Bag-1in 56cases of different grade glioma tissues and 10cases of normal brain tissues was detected by immumohistochemical staining.Results:The expression of Bag-1was significantly higher in glioma tissues than that of normal brain tissues.The positive expressions rate of Bag-1was 69.64%in human glioma tissues,with 40.91%in low level group(gradeⅠ-Ⅱ)and 88.24%in high level group(gradeⅢ-Ⅳ).The positive expression rate of Bag-1in gliomas of gradesⅠ-Ⅱwas significantly higher than that in gliomas of gradesⅢ-Ⅳ(P0.05).The difference in survival time2years group and less than 2years group was also significant(P0.05).Conclusions:Bag-1may play an important role in the development process of gliomas,and may act as valuable indicator of the malignant degree of glioma and the prognosis in the patients with glioma.