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The expression of insulin-like growth factor-I receptor in human glioma and its significance

Wen Zhi-hua

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Abstract

Objective:To explore the expression and distribution of insulin-like growth factor-Ⅰ receptor(IGF-IR) in normal brain and human glioma tissues,and the relationship between its expression and MIB-1.Methods:Expression of IGF-IR and MIB-1 was assessed by immunohistochemistry S-P staining in 55 cases of gliomas and 10 normal brain tissues.Results:The positive rate in gliomas was higher than that in normal brain tissues(P0.05).We also found there was a significant difference between low grade(WHO Ⅰ-Ⅱ) and high grade(Ⅲ-Ⅳ) of gliomas(P0.05).There was correlation between IGF-IR expression and MIB-1(rs=0.735,P0.01).Conclusion:IGF-IR played an very important role in the genesis and development of human gliomas and it may be an adjuvant index of diagnosing glioma and estimating prognosis.

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Objective:To explore the expression and distribution of insulin-like growth factor-Ⅰ receptor(IGF-IR) in normal brain and human glioma tissues,and the relationship between its expression and MIB-1.Methods:Expression of IGF-IR and MIB-1 was assessed by immunohistochemistry S-P staining in 55 cases of gliomas and 10 normal brain tissues.Results:The positive rate in gliomas was higher than that in normal brain tissues(P0.05).We also found there was a significant difference between low grade(WHO Ⅰ-Ⅱ) and high grade(Ⅲ-Ⅳ) of gliomas(P0.05).There was correlation between IGF-IR expression and MIB-1(rs=0.735,P0.01).Conclusion:IGF-IR played an very important role in the genesis and development of human gliomas and it may be an adjuvant index of diagnosing glioma and estimating prognosis.

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Available abstract

Objective:To explore the expression and distribution of insulin-like growth factor-Ⅰ receptor(IGF-IR) in normal brain and human glioma tissues,and the relationship between its expression and MIB-1.Methods:Expression of IGF-IR and MIB-1 was assessed by immunohistochemistry S-P staining in 55 cases of gliomas and 10 normal brain tissues.Results:The positive rate in gliomas was higher than that in normal brain tissues(P0.05).We also found there was a significant difference between low grade(WHO Ⅰ-Ⅱ) and high grade(Ⅲ-Ⅳ) of gliomas(P0.05).There was correlation between IGF-IR expression and MIB-1(rs=0.735,P0.01).Conclusion:IGF-IR played an very important role in the genesis and development of human gliomas and it may be an adjuvant index of diagnosing glioma and estimating prognosis.

Key concepts: Glioma, Immunohistochemistry, Insulin-like growth factor, Human brain, Receptor, Growth factor, Significant difference, Biology

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