2009•Chinese Journal of Birth Health & HeredityRequires access

Chromosome karyotyping of 220 cases of early spontaneous abortion

Qingzhi Liu

Abstract

Objective:To investigate cause of missed abortion.Methods:Choronic villi from 220 cases of missed abortion were sampled.Tissue culture and karyotype analysis was performed on these samples.Results:The successful cell culture rate was 96.36%(212/220).There were 207(97.64%) cases succeeded in karyotype analysis and 115 cases (55.56 %) with chromosome abnormality among 207 cases.Abnormal karyotypes included 72 cases of trisomy,16 cases of monosomy X,14 cases of polyploid,10 cases of chimera and 3 structural abnormity.Conclusion:Chromosome abnormalities was the most important reason in missed abortion,and karyotype analysis of chorionic villus has important clinical significance.

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Key concepts: Karyotype, Abortion, Chorionic villi, Products of conception, Chromosomal Abnormality, Monosomy, Chromosome abnormality, Trisomy