Effects of Losartan on cardiac and renal functions in elderly hypertensive patients

Objective To investigate the clinical effects of Losartan on ventricular and renal functions in elderly hypertensive patients. Methods Forty-three elderly hypertensive patients were treated with Losartan,50-100 mg·d~-1 for twelve to seventeen months ,left ventricular mass index (LWMI),left ventricular function, renal arterial structure, blood and urine β2-MG before and after treatment were determined. Results After treatment the blood pressure in patients had reduced effectively (P0.001).LVM (P0.01) and LVMI (P0.02) were obviously reduced, E/A was increased(P0.01).Thickness of renal arterial wall was significantly decreased (P0.01),the renal arterial diameter was obviously increased (P0.05), β2-MG levels in blood and urine were obviously decreased after treatment (P0.01).Conclusion Losartan can effectively reduce blood pressure, it also can reverse left ventricular hypertrophy (LVH) and improve the function,especially the left ventricular diastolic function and increase the renal blood flow and improve the renal vessel structure, decrease the concentrations of β_2-MG in blood and urine ,and then improve renal function.