Relationship between Lipoprotein(a) and severity of coronary artery stenosis and incidence of myocardial infarction

Objective To study the relationship between serum lipoprotein(a)[Lp(a)]level with severity of coronary artery stenosis and the incidence of myocardial infarction.Methods Totally 384 patients who underwent coronary angiography were included.First,they were divided into four groups according to the number of coronary artery stenosis;normal control group,single vessel disease group,double vessels disease group and three vessels disease group.Secondly, they were divided into three groups according to the diagnosis;normal control group,angina petoris group and myocardial infarction group.Then serum Lp(a) level was compared among different groups.Results Compared with normal control group,serum Lp(a) level was significantly higher in all the groups of patients with coronary artery disease.Among which, serum Lp(a) level was significantly higher in myocardial infarction group than angina pectoris group.No marked difference in serum Lp(a) level was found among groups of single vessel disease,double vessels disease and three vessels disease, but serum Lp(a) concentration was positively correlated with Gensini score of coronary stenosis(partial correlation coefficient (r = 0.143,P0.01).Conclusion Serum Lp(a) level is positively correlated with the degree of coronary artery stenosis and is also closely correlated with myocardial infarction.