The incidence of osteoporosis and analysis of bone metabolic and biochemical markers in patients with type-2 diabetes mellitus

Objective To explore the incidence of osteoporosis and the change of bone metabolic and biochemical markers in patients with type-2 diabetes mellitus.Methods ①142 type-2 diabetes mellitus patients were selected to measure the bone mass in the radius using quantitative ultrasound(QUS) and the biochemical markers of bone metabolism,including bone GLa protein(BGP),urine cross-linked C-telopeptide of type I collagen(CTX-1),serum calcium(Ca),serum phosphorus(P),and alkaline phosphatase(ALP).Incidence of osteoporosis was calculated in male and female diabetic patients,respectively.The results were compared with those in non-diabetic control subjects;② The relationship between the speed of sound(SOS) in the radius in diabetic patients and the age,course of the disease,metabolic control level,and body mass index(BMI) was analyzed.③The patients with type-2 diabetes were divided into following 3 groups according to the bone quantitative ultrasound results: osteoporosis group,low bone mass group,and normal bone mass group.Biochemical markers of bone metabolism among groups were compared.The results were also compared to those in control group.Results ① The incidence of osteoporosis in patients with type-2 diabetes mellitus was significantly higher than those in non-diabetic people.②SOS in diabetic patients was negatively correlated with age,course of the disease,urine CTX,and BMI,and no correlations were found with BGP,HbA1C,and FBG.③ Urine CTX of patients in osteoporosis group was significantly higher than that in low bone mass group and normal bone mass group(P 0.05).Serum PTH of patients in osteoporosis group was significantly higher than that in normal bonemass group.Serum Ca,P,ALP,and BGP had not obvious difference among different groups(P 0.05).BGP of diabetic patients was decreased significantly(P 0.05),and the level of urine CTX was increasedsignificantly(P 0.05),compared to that of non-diabetic control subjects.Conclusion The patients withtype-2 diabetes mellitus were vulnerable to osteoporosis.Their bone metabolism changes included decreasedbone formation and increased bone absorption.The abnormal bone metabolism in type-2 diabetes mellituswas related to many factors.We should pay attention to the prevention and treatment of osteoporosis during the treatment of diabetes.