Observation on the bone density and bone metabolism of 43 patients with type 2 diabetes mellitus.

Objective To discuss the factors associated with osteoporosis in patients with type 2 diabetes mellitus and pathogenesis. Methods 43 patients with type 2 diabetes mellitus including 23 males and 20 females and healthy control inclduing 21 males and 22 females were selected. Single photon absorption was ued to determine the bone mineral density(BMD)of the elbow bone and radial bone. ELISA was used to determine serum osteocalcin(BGP),urine deoxypyridinoline(DPD). Results The BMD of type 2 diabetes mellitus patients are lower than normal control group,The BGP and DPD in the diabetes group were significantly higher than the normal controls (P0.01). Conclusion Bone formation in type 2 diabetes mellitus patients is decreased and bone absorption is increased. The incidence of osteoporosis in type 2 diabetes mellitus patients is high. It is of great significance to prevent and cure the osteoporosis in patients with type 2 diabetes mellitus early.