Analysis of impedance gastric motility of patients with functional dyspepsia

Objective To investigate the significance of RomeⅢclassification by analyzing the characteristics of gastric electrical activity and gastric impedance of patients with functional dyspepsia(FD).Methods One hundred and sixty-two outpatients with FD visiting our hospital from Oct.2008to Dec.2009were divided into PDS group(postprandial distress syndrome patients,n=99)and EPS group(epigastric pain syndrome patients,n=63),and 32healthy people were entered as controls.The postprandial electrical signal and impedance signal were determined by impedance gastric motility instrument.The pathogenesis of FD and its subtypes were analyzed.Results Compared with that in healthy people,the distribution percentage of intermediate frequency(IF)gastric electrical activity was decreased significantly,that of low frequency(LF)gastric electrical activity was increased in PDS group,while that of the high frequency(HF)gastric electrical activity was increased significantly in EPS group.The distribution percentage of LF gastric electrical activity was higher,and that of HF gastric electrical activity was lower significantly in PDS group than in EPS group(P0.017),but no obvious difference was found between the two groups in the distribution percentage of IF gastric electrical activity.The distribution percentage of LF gastric impedance was higher,while the IF and HF gastric impedance were lower significantly in PDS group than in EPS group(P0.017).Conclusions Gastric motility disorder is one of the pathogenetic factors of FD.The pathogenesis of PDS is different from that of EPS,so the classification of RomeⅢmay be beneficial for the option of treatment stratigy FD.