Effects of domperidone on impedance gastric motility of patients with functional dyspepsia

Objective To observe the effects of domperidone on the symptoms and impedance gastric motility of patients with functional dyspepsia (FD) subtypes-postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS).Methods A total of FD 57 patients (according to Rome Ⅲ),who were treated in our hospital during Oct.2008 to Apri.2009,were included in the present study.The symptoms of patients FD were scored before and after treatment with domperidone for 2 and 4 weeks.Domperidone 10 mg was given 3 times daily.The postprandial gastric motility was tested before and after domperidone treatment for comparison.Results Domperidone significantly decreased the scores of postprandial abdominal distention,early satiety,upper abdominal pain and abdominal burning in PDS and EPS group 2 weeks after domperidone treatment (P0.05);4 weeks after treatment,all the symptoms were improved except for the upper abdominal burning in the PDS group and early satiety,upper abdominal pain in the EPS group (P0.05).The differences in percentages of the power of electrogastrogram dominant frequency were significantly different between PDS and EPS patients before and after treatment for 2 and 4 weeksP0.05).Two weeks after treatment,the percentages of the power of the dominant frequency for impedance gastrogram in PDS patients were significantly higher than that before treatment,and significantly lower than that 4 weeks after treatment (P0.05).The percentages of the power of the dominant frequency of impedance gastrogram in EPS patients before and 2 weeks after treatment were significantly lower than those 4 weeks after treatment (P0.05).Conclusion Domperidone can significantly relieve the clinical symptoms,improve electrical signal and impedance gastric motility in PDS and EPS patient after 4 weeks,with the effect obviously better than that after 2weeks.