Protective effects of Shuangshensu capsules on experimental myocardial ischemiareperfusion injury in rats

Objective To study the protective effects of Shuangshensu capsules(SSC) on experimental myocardial ischemia-reperfusion injury in rats.Methods The rat myocardial ischemia-reperfusion model was developed by 30 min left anterior descending coronary occulusion and 24 h reperfusion in open chest anesthetized rats.The activities of aspartate aminotransferase(AST) and other Myocardial enzymes were determined.Results In rats treated with SSC(35 and 70 mg/kg i.g for 7 d),the myocardial ischemia size was significantly reduced(P0.05 or P0.01),the AST,LDH and CK-MB activities and the MDA content in serum declined(P0.05 or P0.01),while the SOD and GSH-Px activities in serum increased significantly(P0.05 or P0.01).In addition,the ET and AngⅡ levels in plasma also declined markedly.Conclusions SSC have protective effects on myocardial ischemia-reperfusion injury.