Expression of survivin and VEGF and its relationship with non-small cell lung cancer

Objective To evaluate the expression and its relationship between survivin and VEGF in non-small-cell lung cancer (NSCLC).Methods We had used the method of S-P immunohistochemical techniques to test the expression level of survivin and VEGF about 35 tissue specimen who have the chemotherapy history and 35 tissues who have non-chemotherapy history of NSCLC cases,comparing the cor- relationship between the expression of survivin and VEGF,analysing the relation with the survival rate.Re- sults The positive expression rate of survivin and VEGF was 74.3% and 70.0%.Survivin and VEGF have positive correlation in the expression of lung cancer tissues (P=0.032,r=0.527),and the survival time of NSCLC person who was accepted chemotherapy in the negative expression of survivin and VEGF was the longest.Conclusion Survivin and VEGF had positive correlation in the expression of NSCLC,the combine detection of survivin and VEGF had played an important part in the chemotherapy and prognosis of non- small-cell lung cancer.