2007•Modern Journal of Integrated Traditional Chinese and Western MedicineRequires access
Expression and significance of CD_4~+CD_(25)~+ regulatory T lymphocytes in child with idiopathic thrombocytopenic purpura
TU Ya-lan
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Abstract
Objective It is to discuss the expression and significance of CD4+CD25+ regulatory T lymphocytes in child with idiopathic thrombocytopenic purpura(ITP).Methods The ratio of the peripheral T lymphocyte subgroup in 27 children with ITP and 21 healthy children and the expression ratio of CD25,FasL and Fas on CD4+ T lymphocytes surface were detected with flow cytometry.Results CD3,CD4 and CD4/CD8 ratio in obviously lower than that in control group,CD4+CD25+ regulatory T lymphocytes obviously decreased,CD4+CD25-lymphocytes had no obvious changes,CD4+FasL+ lymphocytes was increased and CD4+Fas+ lmyphocytes was decreased.Conclusion CD4+CD25+ regulatory T lymphocytes in ITP children were significantly decreased,destroyed autospecific immune tolerance and played an important role in the pathogenesis of ITP.