Observation of clinical curative effects on Quetiapine combined with Citalopram in the treatment of senile depression

Objective To investigate the clinical curative effects and safety of Quetiapine combined with Citalopram in the treatment of senile depression.Methods Sixty patients with senile depression were randomly divided into two groups,with 30 patients in each group.The control group received the oral administration of Citalopram and the study group received the oral administration of Quetiapine combined with Citalopram.The Hamilton depression rating scale(HAMD),geriatric depression scale(GDS) and drug side effects symptom scale(TESS) were used for assessment before the treatment and 1,2,4 and 8 weeks after treatment.Results In the treatment of patients with senile depression,the study group was significantly different from the control group in the HAMD and GDS scores(P 0.01),but not significantly different in the drug side effects(P 0.05).Conclusion In the treatment of patients with senile depression,Quetiapine combined with Citalopram is fast,effective and safe,thereby suitable for clinical application.