Morphine-sparing effect of lornoxicam for postoperative analgesia

Objective:To investigate the morphine-sparing effect of intravenous lornoxicam for postoperative patient-controlled analgesia(PCIA).Methods:69 patients(ASAI-II) undergoing selective upper abdominal procedure were randomly divided into three groups: morphine alone 0.25 mg.ml-1 at the end of the procedure(group M),adding lornoxicam 8mg at the end of the procedure and at the 8 hours after operation to the morphine regimen respectively(group L2) or adding lornoxicam 8 mg at the end of procedure and at the 8 hours and 16 hours after operation to the morphine regimen respectively(group L3),VAS were used to evaluate the analgesic response.Results:Patients in the three analgesic groups did not show significant differences in the VAS values(P0.05).Total morphine consumption,PCA pressing times and effective times in the patients in group M were significantly more than those in group L2 and group L3(P0.05).The incidence of nausea and lethargy was highest in group M,and the incidence of dizziness was the same in all the group.Conclusion:The dual add-on postoperative intravenous administration of lornoxicam to the morphine regimen can spare morphine consumption and decrease side effects.