Effects of lornoxicam on patient controlled analgesia in patients after open heart surgery

AIM: To observe the effects of lornoxicam on patient controlled analgesia in patients after open heart surgery. METHODS: Thirty patients were randomly allocated to lornoxicam group (n=15) and morphine group (n=15). Both groups received PCA (patient controlled analgesia) with morphine (1 mg/mL). The PCA parameters were morphine loading dose of 1 mg,continuous infusion dose of 0.5 mg/h, single dose of 1 mg, lockout time of 10 min, and 4 hours limit of 20 mg. Lornoxicam group received intravenous lornoxicam of 8 mg while the PCA pump beginning, 12, 24 and 48 h after the first dose. Morphine group received intravenous normal saline at the same four points. The following indexes were recorded at 12, 24, 36 and 48 h after the PCA pumps were used: VAS scores of pain, effective pressing numbers, drug dosage, sedation degree, side effects, and patient satisfaction. RESULTS: There were no significant difference in VAS scores of pain at 12, 24, 36 and 48 hours after the PCA pumps were used(P0.05). The VAS scores of pain, effective pressing numbers and drug dose in lornoxicam group were obviously lower than those in morphine group(P0.05). The incidence rate of nausea in lornoxicam group was obviously lower than that in morphine group(P0.05), and there were no significant difference of the other side effects(P0.05). There were no significant difference in patient satisfaction degree, residence time in ICU and length of stay after operation(P0.05). CONCLUSION: Lornoxicam can relief pain in patients after open heart surgery safely and efficiently, and reduce the morphine consumption.