Effect of ovulation induction treatment on endometrial polyps formation in patients with infertility

Objective To study the relationship between ovulation induction treatment and endometrial polyps formation in the patients with infertility,and to clarify the factors which influence the formation of endometrial polyps during ovulation induction treatment.Methods The data was collected from 76 infertile patients who had received ovulation induction treatment and came to outpatient service for hysteroscopy.The statistical analysis of the relationship between ovulation induction and endometrial polyps formation was performed in terms of infertility types,infertility duration,ovulation induction cycles and presence of gonadotrophin releasing hormone analogue(GnRHa)in the treatment.Results The occurence rates of endometrial polyps between the patients with different infertility types(χ2= 0.071,P=0.790)or the different durations of intertility(χ2= 1.561,P=0.458)had no significant differences while the occurrence rates between the patients with different ovulation cycles(χ2= 4.992,P=0.025)or whether to use GnRHa(χ2=18.899,P=0.000)had significant differences.The occurrence rate of endometrial polyps was increased as the cycles of ovulation induction was increased.The occurrence rate of endometrial polyps was twice higher in the patients with three or more cycles of ovulation induction than that in the patients with one or two cycles(52.4% vs 25.5%,P=0.025).Meanwhile,the occurrence rate in the patients treated with GnRHa was significantly lower than that in the patients treated without GnRHa(16.0% vs 65.4%,P=0.000).Conclusion The increase of cycles of ovulation induction is a risk factor for endometrial polyps while the presence of GnRHa in the treatment is a protective factor against the formation of endometrial polyps.