Analysis on clinical effect of GnRHa-induced ovulation

Objective:To observe the clinical effect of GnRHa in triggering ovulation.Methods:328 patients with polycystic ovary syndrome(1 259 ovulation induction cycles)were analyzed retrospectively and divided into study group and control group randomly,the patients with diameter of follicles≥16 mm,number of follicles6 and/or diameter of ovary≥6 cm were classified as experimental group,then they were injected subcutaneously with triptorelin 0.1 mg,once a day(n=736 cycles);the patients in control group were injected intramuscularly with chorionic gonadotropin 10 000 U,once a day(n=523 cycles),the therapeutic effects were compared between the two groups.Results:There was no significant difference in average age,infertility duration,basic endocrine situation,endometrial thickness on the day of ovulation between the two groups(P0.05);there was no significant difference in ovulation rate,pregnancy rate and multiple pregnancy rate between the two groups(P0.05);there was significant difference in incidence of middle-severe OHSS and number of ovulation between the two groups(P0.05);there was no significant difference in ovulation rate in hierarchical comparison of the number of dominant follicles between the two groups(P0.05).Conclusion:The ovulation rate and pregnancy rate in ovulation induced by 0.1 mg GnRHa are similar to those in HCG group,which can reduce the occurrence of OHSS effectively;but in GnRHa-induced ovulation group,the number of ovulation is higher than that in HCG group,pregnancy rate and multiple pregnancy rate are similar to those in HCG group,which are related to corpus luteum insufficiency after ovulation induced by GnRHa probably.