Research on use of low-dose aspirin in the process of promoting ovulation to improve endometrial development

Objective:To analyze the clinical value of using low-dose aspirin during ovulation to improve endometrial development.Methods:50 cases of infertility due to ovulatory dysfunction and female patients were collected and divided into study group and control group with 25 caseseach.The control group received clomiphene treatment,and the research group received aspirin(75 mg·d-1) treatment on the basis of clomiphene.Results:1 d before ovulation,TXA2 level and TXA2 / PGI2 ratio of study group were significantly lower than those of the control group.Compared with the control group,uterine artery RI in the study group 1d before ovulation was significantly lower,with endometrial thickness more significantly obvious(P0.05).Compared with the control group,endometrial thickness in the study group after ovulation was significantly higher(P0.05).Compared with the control group,the interstitial area,perimeter and glandular gland / room ratio in the study group 10 d after ovulation endometrial area,were significantly greater(P0.05).Compared with the control group,endometrial ER,PR endometrial in the study group 10 d after ovulation were significantly higher(P0.05).Conclusion:During ovulation,the use of low-dose aspirin therapy was helpful to increase blood supply to the uterus,promote the development of endometrial thickening,and improve the pregnancy rate.