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2004•Journal of Modern StomatologyRequires access

The correlation between bone density and mRNA expression of TGF-β1 in the alveolars with experimental diabetic rats

Jian Chen

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Abstract

Objective To study the correlation between bone density and mRNA expression of TGF-β1 in the alveolars with experimental diabetic rats.Methods Twenty SD rats were randomly divided into following groups: normal group and diabetic group.At the 8th weeks ,TGF-β1 mRNA expression in the alveolars were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR),respectively.In addition, radiograph,bone density and pathology were examined.Results In diabetic group,the alveolar bone density was decreased,and mRNA expression of TGF-β1 was increased.Conclusion It is suggested that the alveolar bone in rats with diabetes had a tendency to develop osteoporosis.It might be related with increased TGF-β1 mRNA expression.

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What this paper is about

Objective To study the correlation between bone density and mRNA expression of TGF-β1 in the alveolars with experimental diabetic rats.Methods Twenty SD rats were randomly divided into following groups: normal group and diabetic group.At the 8th weeks ,TGF-β1 mRNA expression in the alveolars were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR),respectively.In addition, radiograph,bone density and pathology were examined.Results In diabetic group,the alveolar bone density was decreased,and mRNA expression of TGF-β1 was increased.Conclusion It is suggested that the alveolar bone in rats with diabetes had a tendency to develop osteoporosis.It might be related with increased TGF-β1 mRNA expression.

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Available abstract

Objective To study the correlation between bone density and mRNA expression of TGF-β1 in the alveolars with experimental diabetic rats.Methods Twenty SD rats were randomly divided into following groups: normal group and diabetic group.At the 8th weeks ,TGF-β1 mRNA expression in the alveolars were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR),respectively.In addition, radiograph,bone density and pathology were examined.Results In diabetic group,the alveolar bone density was decreased,and mRNA expression of TGF-β1 was increased.Conclusion It is suggested that the alveolar bone in rats with diabetes had a tendency to develop osteoporosis.It might be related with increased TGF-β1 mRNA expression.

Key concepts: Messenger RNA, Osteoporosis, Reverse transcription polymerase chain reaction, Diabetes mellitus, Internal medicine, Endocrinology, Reverse transcriptase, Transforming growth factor

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