Clinical evaluation of tumor markers MG-7,CEA,CA19-9 and CA72-4 in the diagnosis and the prognostic judgment of gastric carcinoma

Objective To explore the clinical significance of the combined detection of tumor markers MG-7,CEA, CA19-9 and CA72-4 in the diagnosis and the prognostic judgment of gastric carcinoma.Methods The four tumor markers were detected by ELISA or chemiluminescent methods in 60 healthy controls,60 patients with gastritis,56 patients with cancers out of stomach and 60 patients with gastric carcinoma before the operation and in three months after the radical operation.Results The serum levels of MG-7,CEA,CA19-9 and CA72-4 in the patients with gastric carcinoma before operation were(7.0±5.1)U/ml,(76.6±264.4)μg/L,(84.8±187.7)U/ml and(47.6±88.6)U/ml,respectively,which were high- er than those in either of the other groups.The combined detection of the four tumor markers had higher sensitivity than the single detection of the each tumor marker.The serum levels of MG-7,CEA,CA19-9 and CA72-4 in the patients with gastric carcinoma in three months after the radical operation were obviously lower than those before the operation.Con- clusions The combined detection of MG-7,CEA,CA19-9 and CA72-4 could improve the sensitivity of diagnosis in gas- tric carcinoma.Changes of the serum MG-7,CEA,CA19-9 and CA72-4 levels have significant value in the diagnosis and the evaluation of therapeutic effect.