Diagnostic value of CEA,CA72-4 and CA19-9 in gastric cancer

Objective To discuss the diagnostic value of serum tumor markers carcinoma embryonic antigen(CEA),CA72-4 and CA19-9 in the patients with gastric cancer.Methods The serum levels of CEA,CA72-4and CA19-9 were measured by chemiluminescence immunoassay(CLIA) and electrochemiluminescence immunoassay(ECLIA) in 104 patients with gastric cancer,43 patients with benign gastric diseases and 51 healthy persons.Results Serum levels of four tumor markers in the patients with gastric cancer were higher than those in benign gastric disease group and healthy control group(P0.05).There was no significant difference between the benign gastric disease group and healthy control group(P0.05).The areas under the curve(AUC) of CEA,CA19-9 and CA72-4 were 0.778,0.670 and 0.715 respectively by application of ROC curve.The cut off value of CEA was 4.7 ng/mL,which resulted in 51.2% sensitivity and 95.7% specificity.The cut off value of CA19-9 was 28 U/mL,which resulted in 43.0% sensitivity and 95.7%specificity.The cut off value of CA72-4 was 6.3 U/mL,which resulted in 29.1% sensitivity and 94.7% specificity.Compared to single detection,the sensitivity detection of the three tumor markers were improved significantly.Conclusion CEA,CA19-9 and CA72-4 have the good diagnostic value to gastric cancer.CEA is the most effective tumor marker of gastric cancer.Combined detection of serum tumor markers CEA,CA72-4 and CA19-9 can improve the sensitivity of gastric cancer.