A Study on Expression of p73 Protein in Epithelial Ovarian Neoplasms

Objective To study the expression of p73 protein and to analyze their roles in epithelial ovarian tumors . Methods The expression of p73 protein in 15 cases of benign ovarian tumor, 12 cases of borderline ovarian tumor, 50 cases of ovarian carcinomawas and 15 cases of normal ovarian tissues were analyzed by immunohistochemical technique. Results The Expression of p73 protein was 26.7% ( 4/15 ) in benign ovarian tumors, 50% (6/12) positive in borderline tumors, 13.3% (2/15) in normal tissue and 76%(38/50) in ovarian epithelial malignant tumors. There was an obvious difference in the expression of p73 between malignant and borderline tumors, the same result a ppeared in the group of malignant tumors and normal tissue(P0.05).ln the malignant tumor group had no relation with to borderline ovarian tumor(P0.05). The Expression of p73 protein had a relationship with the Neoplasms type: phlegm tumors' p73 protein had a high expression in the nucleolus, while the serosity tumors in the cell plasma. Conclusion p73 Gene takes part in the development of malignant epithelial ovarian tumors with high expression. The type of mutant p53 gene may be used as an indicator of judging benign and malignant tumors in epithelial ovarian tumors. Tile type of p73 Gene expression has a correlation with the type of Neoplasms.