Relationship of Carotid Intima-media Thickness with Serum High Sensitive C-reactive Protein and Insulin Resistance Risk Factors in Type 2 Diabetes Mellitus

Objective To evaluate the relationship of carotid intima-media thickness (IMT) with risk factors of insulin resistance and serum hs-CRP level in type 2 diabetic subjects.Methods Carotid IMT by ultrosonography and serum hs-CRP level were measured for 92 patients of type 2 diabetes (group A of 48 subjects with atherosclerosis,group B of 44 subjects without atherosclerosis),their BMI,HbA_ 1c ,plasma lipids and insulin resistance index (HOMA-IR) were also measured and analyzed.Results In group A mean carotid IMT and hs-CRP level HOMA-IR,BMI,TC,LDL-C were higher than group B,HDL-C was lower than group B.Carotid IMT was correlated with hs-CRP,TC,LDL-C,HOMA-IR,BMI;IMT was also related with HbA_ 1c in Group A.There was statistical significance in the above data analysis.Conclusion The carotid IMT in T2DM is associated with serum hs-CRP and insulin resistance risk factors,which contribute to atherosclerosis at different degrees.