An contrast study of autologous bone marrow mesenchymal stem cells transplanted into ischemic myocardium from intravenous way or myocardium way

Objective To contrast the improvement of cardiac function by transaplanting bone marrow mesenchymal stem cells(MSCs)from intravenous way or myocardium way.Methods 30 rabbits were divided randomly into 3 groups after the left anterior descending branch of coronary artery(LAD) was ligated:trauma control group,intravenous transplantation group,myocardium transplantation group.Five weeks later,the heart function was evaluated and DAPI labeled cells were detected.Results DAPI labeled cells were found in ischemic region,left ventricular function was increased significantly in intravenous and myocardium transplanting group(P0.05).But left ventricular function of myocardium transplantation group is better(P0.05).Conclusion Intravenously transplanted MSCs can diffrentiate into myocardium-like cell and improve rat damaged cardiac function.In this research,myocardium transplatation group achieved better improvement of left ventricular function.