DISTRIBUTION AND DRUG RESISTANCE OF PATHOGENIC BACTERIA IN BLOOD CULTURES IN 4 YEARS

[Objective]To investigate the distribution and drug resistance of pathogenic bacteria in blood culture so as to provide a basis for rational use of antibiotics in clinic.[Methods]Blood specimens,collected from outpatients and inpatients during 2006-2009 in our hospital,were cultured and drug sensitivity tests were conducted.The distribution and drug resistance of pathogenic bacteria in blood culture were studied and analyzed.[Results]Among all the blood samples in the past four years,633 strains of pathogenic bacteria were isolated.The positive isolating rate was 10.31%(633/6 135).240 strains of gram-negative bacteria were isolated,the annual detection rate was 37.91%.354 strains of gram-positive bacteria were isolated,the annual detection rate was 55.92%.39 strains of monilia,annual detection rate was 6.16%.Staphylococcus aureus,Escherichia coli and Staphylococcus epidermidis were three dominant strains,the annual detection rate was 18.17%,15.64%,17.22% respectively.The drug resistances of gram-negative bacteria to AMP,TZP,CFP,ATM were different in 2006 and 2009(P﹤0.05),the drug resistances of gram-positive bacteria to P,CTX,LEV,DA,AZM were increased and different in 2006 and 2009(P﹤0.05).The sensitivities of gram-negative bacteria and gram-positive bacteria to imipenem and vancocin were 1.92% and 0.68% respectively.[Conclusion]Staphylococcus aureus and Escherichia coli are the most common pathogens in gram-positive bacteria and gram-negative bacteria,respectively.Drug resistance of isolated pathogenic bacteria in blood cultures is prevalent and serious.Monitoring the changes of pathogens and trends of drug resistance is vital.