The Effect of Astragalosides(AST)on Hemodynamics and Antioxidation in Ventricular Remodeling Rats

Objective To observe the effect of astragalosides(AST)on hemodynamics and antioxidation in ventricular remodeling rats.Methods The ventricular remodeling model was induced by myocardial infarction in rats of left anterior descending coronary occulusion.The wistar rats were divided into 4groups,including Blank control group,model control group,AST group and positive control group(captopril).The rats in AST group and positive control group were treated with respectively AST 50mg/kg and captopril 100mg/kg,the rats in sham operation group and model control group were treated with equal volume of 0.5% sodium carboxymethyl cellulose Solution,1times a day for 4weeks.After 4weeks,hemodynamics,body weight,left ventricular absolute weight and the relative weight of the left ventricle were measured;the serum malondialdehyde(MDA),superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)activity were measured;myocardial collagen content and I/III collagen ratio were measured in each group.Results AST could significantly reduce LVEDP of model group rats,increase MAP,± dp/dtmax of model control group;AST could significantly reduce left ventricular absolute weight and the relative weight of the left ventricle model control group;AST could significantly reduce myocardial collagen content and I/III collagen ratio;AST could significantly decrease MDA content and increase the activity of SOD,GSH-Px.Conclusion AST has protective effect on experimental ventricular remodeling,which mechanism may be related to inhibiting myocardial interstitial fibrosis and enhance the body's antioxidant capacity.